To mitigate the "lost in the middle" effect, critical instructions should be placed:
Answer: At the beginning or end of the system prompt
Attention peaks at the beginning and end of the context (B). Placing critical content in the middle (A) maximizes the risk. Moving to user message (C) changes the instruction trust level. Repeating every 2,000 tokens (D) is a workaround that inflates token count significantly.